We are interested in how extracellular matrices (ECM) regulate tissue architecture and integrity and provide specific cues to cells under homeostatic and disease conditions. The ECM is comprised of collagens, glycoproteins, proteoglycans and growth factors whose relative composition and assembly is fine-tune based on the particular functional demands of the tissue in question.

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    • May 17, 2021

      Our manuscript “Pathogenic alleles in microtubule, secretory granule and extra-cellular matrix related genes in familial keratoconus” by Shinde, Sobreira and others is now in press in Human Molecular Genetics.

    • April 26, 2021 

      Maithê Rocha Monteiro de Barros has joined our lab in April 2021! Welcome Maithê!

    • July 10, 2020

      Our manuscript “RNA sequencing of corneas from two keratoconus patient groups identifies potential biomarkers and decreased NRF2-antioxidant responses” by Shinde, Hu and others is now in press in Scientific Reports.