The Alexandria Center of Science

A postdoctoral position is available immediately to investigate the role of extracellular matrix (ECM) proteoglycans in innate and adaptive immunity. Our previous work on the proteoglycan lumican identified its interactions with TLR-4 signals and lumican-deficient mice were impaired in overcoming bacterial infections. The candidate will work with cell cultures and various null mice to further investigate the link between ECM proteoglycans and immunity. We have an exciting multidisciplinary group with members from Medicine, Cell biology, Immunology and Ophthalmology. The candidate must be highly motivated, within 2 years of completion of a Ph.D. in the areas of immunology (preferred) or cell biology and must have expertise in flow cytometry.

To apply please submit a brief statement of past research accomplishments and future goals along with your CV and request references to be directly sent to Professor Shukti Chakravarti, Department of Ophthalmology and Pathology, NYU School of Medicine.

Email: Shukti.Chakravarti@nyumc.org

Opportunities

for Graduate Students and Postdoctoral Fellows

Dr. Chakravarti is committed to mentoring new graduate students. Below are some research topics that may be of interest to potential students.

  • Genetic studies of keratoconus on familial and isolated cases using whole genome and exome sequencing approaches.
  • Gene editing in induced pluripotent stem cells and development of cornea organoids for functional studies of novel keratoconus variants. These studies will establish functions of novel genes in the cornea and their relevance to corneal diseases.
  • ECM-immune cell interactions and their implications in infections and autoimmunity. Lumican, decorin, biglycan and fibromodulin are proteoglycans of the ECM that collagen fibril architecture and interact with immune cells. We have several projects that are ready to address how these proteoglycans interact with immune cells and their consequences on innate and adaptive immunity.